Herpesvirus and risk of stroke
12 Dec 2018
Herpes zoster, caused by reactivation of the chickenpox virus, is linked to an increased risk of stroke, according to a recent systematic review by Harriet Forbes and colleagues. In the review, the risk of stroke approximately doubled in the week after herpes zoster and gradually returned to baseline over the next six months. While recent infection with, or reactivation of, other members of the...
Use of Angiotensin-Converting Enzyme (ACE) Inhibitor or Angiotensin Receptor Blocker (ARB) after Actute Kidney Injury
15 Nov 2018
ACE Inhibitors and ARBs are drugs that have transformed clinical care. There is strong randomised trial evidence for improved clinical outcomes from these drugs for patients with heart failure with reduced left ventricular function, and for proteinuric kidney disease. They are also recommended for use for the treatment of hypertension and after ischaemic heart disease. These multiple indications...
Trimethoprim and adverse outcomes in older patients
21 Mar 2018
Members of our group have recently published a paper investigating adverse effects of trimethoprim for the treatment of urinary tract infection. We show that compared to other antibiotics used for the same reason, trimethoprim is associated with an increased risk of acute kidney injury (a sudden reduction in kidney function) and high potassium levels but not an increased risk of death. Both of...
International Conference on Pharmacoepidemiology and Therapeutic Risk Management – Montreal Aug 2017
11 Sep 2017
Sam Wilkinson & Ian Douglas Sam’s thoughts: As a new student of pharmacoepidemiology- and a first-time attendee of ICPE- I was initially overwhelmed. All the sessions seemed relevant and interesting, and the first challenge was to use the time efficiently. By the end though, I felt encouraged. My research focuses on Type 2 Diabetes drugs, and I spent most of my time attending...
Where did statistical software come from?
31 Jul 2017
Sarah C Gadd, John Tazare A hugely important part of studying the epidemiology of diseases is being able to use statistics appropriately. Members of the Electronic Health Records group often write code in statistical programming languages in order to process and analyse data, but we rarely discuss how these programs came to exist. A number of developments in computer science were led by a desire...
Barriers and facilitators to linking and sharing routine health data for research
16 Jun 2017
Today Dr Charlotte Warren-Gash discusses ‘Barriers and facilitators to linking and sharing routine health data for research’ on the PHG Foundation blog’
Report from 1st EDEN Forum
24 Apr 2017
By Anna Ascott School researcher, Dr Sinéad Langan helped organise the first European Dermatology Epidemiology Network (EDEN) Forum, which was held on 30-31 March 2017, in Madrid, Spain Dermato-Epidemiology, which describes the study of causes, prevention, health services research and evaluation of interventions of skin diseases, is particularly important for dermatology, as a relatively...
Blog – Availability of clinical trial data for research purposes
19 Apr 2017
By Kevin Wing. I recently attended a session entitled EMA’s Policy on Clinical Publication: Opportunities, Challenges and Measuring Success at the Drug Information Association annual conference in Glasgow, (still just about) UK, focusing on progress of the European Medicines Agency’s (EMA) new policy for making complete clinical trial data available for access by the public and researchers...
PHE Conference and ISPE mid-year meeting
10 Apr 2017
by Andreia Leite. Members of the electronic health records (EHR) group have recently attended two conferences: Public Health England (PHE) Research and Applied Epidemiology Scientific Conference 2017 and ISPE 2017 mid-year meeting. In both, researchers from the group presented work using data from the Clinical Practice Research Datalink (CPRD). PHE conference joined professionals working in...
Funding secured to investigate the effect of partner bereavement on skin diseases
03 Jan 2017
The European Academy of Dermatology and Venerology are funding a programme of work to investigate the effects of partner bereavement on a range of skin diseases. The project is being led by Dr Sinéad Langan and is a collaboration between the LSHTM EHR Research Group, Aarhus University in Denmark and the Clinical Practice Research Datalink. A number of EHR researchers from LSHTM are involved in...
Prize at Biennial Conference of the International Society of Hypertension, Seoul, South Korea, September 2016.
08 Nov 2016
At the end of September, Sarah-Jo Sinnott travelled to Seoul, South Korea to attend and present at the International Society of Hypertension conference. This society has members from all over the world, and the biennial conference provides a forum for the presentation and discussion of all research relating to hypertension, from basic science to clinical science to epidemiological...
Comorbidites in patients with chronic kidney disease – Masao Iwagami
27 Sep 2016
In August 2016, our monthly Journal Club featured a Nephrology article entitled “Comorbidity as a driver of adverse outcomes in people with chronic kidney disease” (M Tonelli et al., Kidney Int., 2015 , 859-66). Chronic kidney disease (CKD), defined as kidney damage (albuminuria or proteinuria) or as decreased kidney function (estimated glomerular filtration rate [eGFR] <60...
ICPE 2016, Dublin
06 Sep 2016
by Anthony Matthews and Sarah-Jo Sinnot Members of the EHR group recently travelled to the 32nd International Conference on Pharmacoepidemiology and Therapeutic Risk Management in Dublin. Not only were several members presenting both talks and posters (see table below), the group also held a successful symposium entitled ‘Optimal Use of Data from United Kingdom Electronic Health Records’