26 Apr

Nephrology Journal Club

26 Apr 2017

Wednesday 26th April’s Nephrology Journal Club is going to be based on a recent paper written by members of out group. Laurie Tomlinson has also written a blog relating to the paper. We hope as many people as possible can get involved here, and using the hashtag #NephJC.

3 Apr

Even small reductions in kidney function after starting common blood pressure drugs are associated with increased risk

03 Apr 2017

Angiotensin converting enzyme inhibitors (ACEI) (drugs with names ending in –pril, e.g. enalapril) and angiotensin receptor blockers (ARB) (drugs with names ending in –sartan, e.g. losartan) are drugs that are commonly used to treat high blood pressure and heart failure. Current guidelines recommend that they should be stopped in people who have a reduction in kidney function (measured using...

30 Mar

New NIHR-funded post to study drug-treatment effects using observational data

30 Mar 2017

Dr Kevin Wing has taken up a 3-year NIHR-funded position to study the effectiveness of drugs for Chronic Obstructive Pulmonary Disease (COPD) within observational data. Using randomised controlled trial individual patient data from and observational data from the Clinical Practice Research Datalink (CPRD), optimal methods for assessing COPD treatment effectiveness in...

9 Mar

How useful are observational data for drug regulatory decision making?

09 Mar 2017

We have just been awarded a grant by the Association of the British Pharmaceutical Industry to determine how observational research using electronic health records is used in the regulatory decision making process in Europe. Every year, many studies about drug risks and benefits are published, and they often rely on the use of electronic health records. What we don’t know is how useful these...

23 Feb

StatinWISE trial testimonial

23 Feb 2017

“StatinWISE will answer a really important question: whether the muscular aches and pains that lots of people have are actually caused by statins. One of the exciting things about the project is the way it brings together individual patient care with research. As well as giving an answer for every individual patient – allowing them to make an informed choice about their future...

22 Feb

New 100 million cohort in Brazil

22 Feb 2017

Working in partnership with Brazilian researchers, we have helped secure Wellcome funding to develop a new biomedical resource: the 100 million Brazilian linked data and datacenter. This resource will be built around “Cadastro-Unico”, a database of electronic records of over 100 million applicants to social protection programmes in Brazil. Records consist of detailed individual information on...

3 Feb

StatinWISE now recruiting!

03 Feb 2017

StatinWISE is a trial designed to find out whether the muscle symptoms experienced during statin use are caused by statins.  Statins are the most commonly prescribed treatment in the UK.  Severe side effects such as rhabdomyolysis are rare, but there is uncertainty about whether statins cause less severe symptoms like muscle pain and cramps.  StatinWISE aims to find out whether statins cause...

30 Jan

Brazilian 100 million cohort

30 Jan 2017

We are working closely with researchers in Brazil to help establish a new cohort of over 100 million Brazilian people based on linked data (led by Professor Mauricio Barreto). The cohort will be built around “CADASTRO-UNICO” a database of electronic records of applicants to  social protection programmes in Brazil. Records consist of detailed individual information on housing conditions,...

23 Jan

Real World Effectiveness of Medications for COPD

23 Jan 2017

We have recently been awarded a three year grant by the UK National Institute for Health Research to study how well medication for COPD works in routine clinical care, and in particular in patients not normally studied in randomised trials. To do this, we’ll be using primary care data from the Clinical Practice Research Datalink linked with Hospital Episode Statistics data. A novel and exciting...

12 Jan

Dr Emily Herrett awarded a post-doctoral fellowship

12 Jan 2017

Dr Emily Herrett has been awarded a post-doctoral fellowship from the NIHR.  The project aims to provide evidence to compare the benefits and harms of two alternative strategies for guiding blood pressure lowering treatment in the UK.  Data from the UK’s Clinical Practice Research Datalink (CPRD) and New Zealand PREDICT will be used.

3 Jan

Sharp fall in GP visits for acute gastroenteritis following introduction of rotavirus vaccination.

03 Jan 2017

Press Release – see more at:

29 Jul

New for 2017!

29 Jul 2016

The highly successful LSHTM training program in Pharmacoepidemiology and Pharmacovigilance is now available by distance learning. The content is the same as for the face to face course, but students can study in their own time and do not need to travel to London. Detail are here:

28 Jul

Your health data: really private and really useful

28 Jul 2016

Why using your health data is such a vital part of keeping the whole population healthy, the safeguards in place, and are the horror scares true? On Wednesday 31 August 2016, Liam Smeeth will be talking about using medical records data for health research and considering the benefits vs. the perceived and real risks. Click here for more information.

22 Jul

New book on the ethics of biomedical big data

22 Jul 2016

Following the publication of the RECORD guidelines, three RECORD associated investigators, including the two co-Chairs, Eric Benchimol and Sinead Langan, in conjunction with Stuart Nicholls from the University of Ottawa have just authored a chapter in the forthcoming book “The Ethics of Biomedical Big Data” (Springer) highlighting new ethical challenges with Big Data. Click here for more...

18 Jul

Pint of Science – Are your healthcare records transforming research?

18 Jul 2016

The EHR related Pint of Science night went down a storm at the Driver pub in Islington on 23rd May. The night started with Sara Thomas, Anthony Matthews, Kevin Wing, and Elizabeth Williamson all presenting their own opinions on why researchers should be allowed access to anonymised health records for the purpose of research, backed up using examples from their own work. Following interval drinks,...

11 Jul

Wellcome Trust Intermediate Clinical Fellowship Awarded

11 Jul 2016

Dr Charlotte Warren-Gash has been awarded a 4 year Wellcome Trust Intermediate Clinical Fellowship. This will fund a programme of work on the role of herpes viruses in dementia and stroke, undertaken in collaboration with University College London. Data sources will include the Dominantly Inherited Alzheimer’s Network cohort (DIAN), the Clinical Practice Research Datalink (CPRD), and UK...

30 Jun

Statins controversy linked to rise in UK patients stopping the treatment

30 Jun 2016

New research highlights potential public health impact of high profile health stories in the media. For more information click here. Anthony Matthews, Emily Herrett, Antonio Gasparrini, Antonio, Tjeerd van Staa, Ben Goldacre, Liam Smeeth, Krishnan Bhaskaran, Impact of statin media coverage on the use of statins in the UK: an interrupted time series analysis using primary care data, BMJ. DOI:...

28 Jun

Methodological Challenges

28 Jun 2016

A paper reviewing methodological challenges when carrying out research on chronic and acute kidney disease published. In this paper we systematically explore the issues that may arise in study design and interpretation when using routine data sources for renal research.

24 Jun

Sir Henry Wellcome Postdoctoral Fellowship Awarded

24 Jun 2016

In May 2016, Dr Rohini Mathur was awarded a four year Sir Henry Wellcome Postdoctoral Fellowship, which will commence in April 2017. The aim of the research will be to identify areas of healthcare which can be modified in order to reduce the risk of vascular disease outcomes amongst people with type 2 diabetes. It is known that significant ethnic inequalities exist, both in the prevalence of...

24 Jun

New Paper: Recent Trends in ADHD medication use in UK

24 Jun 2016

Over the last 20 years, children with attention deficit hyperactivity disorder (ADHD) throughout the world have been increasingly treated with medication. This study used primary care prescribing records to look at ADHD medication trends in the UK. We found large increases in the use of ADHD medication between 1992 and 2008, with usage levels then becoming stable since 2008. This paper is...