Nephrology Journal Club
26 Apr 2017
Wednesday 26th April’s Nephrology Journal Club is going to be based on a recent paper written by members of out group. Laurie Tomlinson has also written a blog relating to the paper. We hope as many people as possible can get involved here, and using the hashtag #NephJC.
Even small reductions in kidney function after starting common blood pressure drugs are associated with increased risk
03 Apr 2017
Angiotensin converting enzyme inhibitors (ACEI) (drugs with names ending in –pril, e.g. enalapril) and angiotensin receptor blockers (ARB) (drugs with names ending in –sartan, e.g. losartan) are drugs that are commonly used to treat high blood pressure and heart failure. Current guidelines recommend that they should be stopped in people who have a reduction in kidney function (measured using...
New NIHR-funded post to study drug-treatment effects using observational data
30 Mar 2017
Dr Kevin Wing has taken up a 3-year NIHR-funded position to study the effectiveness of drugs for Chronic Obstructive Pulmonary Disease (COPD) within observational data. Using randomised controlled trial individual patient data from clinicalstudydatarequest.com and observational data from the Clinical Practice Research Datalink (CPRD), optimal methods for assessing COPD treatment effectiveness in...
How useful are observational data for drug regulatory decision making?
09 Mar 2017
We have just been awarded a grant by the Association of the British Pharmaceutical Industry to determine how observational research using electronic health records is used in the regulatory decision making process in Europe. Every year, many studies about drug risks and benefits are published, and they often rely on the use of electronic health records. What we don’t know is how useful these...
StatinWISE trial testimonial
23 Feb 2017
“StatinWISE will answer a really important question: whether the muscular aches and pains that lots of people have are actually caused by statins. One of the exciting things about the project is the way it brings together individual patient care with research. As well as giving an answer for every individual patient – allowing them to make an informed choice about their future...
New 100 million cohort in Brazil
22 Feb 2017
Working in partnership with Brazilian researchers, we have helped secure Wellcome funding to develop a new biomedical resource: the 100 million Brazilian linked data and datacenter. This resource will be built around “Cadastro-Unico”, a database of electronic records of over 100 million applicants to social protection programmes in Brazil. Records consist of detailed individual information on...
StatinWISE now recruiting!
03 Feb 2017
StatinWISE is a trial designed to find out whether the muscle symptoms experienced during statin use are caused by statins. Statins are the most commonly prescribed treatment in the UK. Severe side effects such as rhabdomyolysis are rare, but there is uncertainty about whether statins cause less severe symptoms like muscle pain and cramps. StatinWISE aims to find out whether statins cause...
Brazilian 100 million cohort
30 Jan 2017
We are working closely with researchers in Brazil to help establish a new cohort of over 100 million Brazilian people based on linked data (led by Professor Mauricio Barreto). The cohort will be built around “CADASTRO-UNICO” a database of electronic records of applicants to social protection programmes in Brazil. Records consist of detailed individual information on housing conditions,...
Real World Effectiveness of Medications for COPD
23 Jan 2017
We have recently been awarded a three year grant by the UK National Institute for Health Research to study how well medication for COPD works in routine clinical care, and in particular in patients not normally studied in randomised trials. To do this, we’ll be using primary care data from the Clinical Practice Research Datalink linked with Hospital Episode Statistics data. A novel and exciting...
Dr Emily Herrett awarded a post-doctoral fellowship
12 Jan 2017
Dr Emily Herrett has been awarded a post-doctoral fellowship from the NIHR. The project aims to provide evidence to compare the benefits and harms of two alternative strategies for guiding blood pressure lowering treatment in the UK. Data from the UK’s Clinical Practice Research Datalink (CPRD) and New Zealand PREDICT will be used.
Sharp fall in GP visits for acute gastroenteritis following introduction of rotavirus vaccination.
03 Jan 2017
Press Release – see more at: http://www.lshtm.ac.uk/newsevents/news/2016/rotavirus_vaccination.html#sthash.AiKoiVQ9.dpuf...
New for 2017!
29 Jul 2016
The highly successful LSHTM training program in Pharmacoepidemiology and Pharmacovigilance is now available by distance learning. The content is the same as for the face to face course, but students can study in their own time and do not need to travel to London. Detail are here: http://www.lshtm.ac.uk/study/cpd/distance_pharmacoepidemiology_pharmacovigilance.html...
Your health data: really private and really useful
28 Jul 2016
Why using your health data is such a vital part of keeping the whole population healthy, the safeguards in place, and are the horror scares true? On Wednesday 31 August 2016, Liam Smeeth will be talking about using medical records data for health research and considering the benefits vs. the perceived and real risks. Click here for more information.
New book on the ethics of biomedical big data
22 Jul 2016
Following the publication of the RECORD guidelines, three RECORD associated investigators, including the two co-Chairs, Eric Benchimol and Sinead Langan, in conjunction with Stuart Nicholls from the University of Ottawa have just authored a chapter in the forthcoming book “The Ethics of Biomedical Big Data” (Springer) highlighting new ethical challenges with Big Data. Click here for more...
Pint of Science – Are your healthcare records transforming research?
18 Jul 2016
The EHR related Pint of Science night went down a storm at the Driver pub in Islington on 23rd May. The night started with Sara Thomas, Anthony Matthews, Kevin Wing, and Elizabeth Williamson all presenting their own opinions on why researchers should be allowed access to anonymised health records for the purpose of research, backed up using examples from their own work. Following interval drinks,...
Wellcome Trust Intermediate Clinical Fellowship Awarded
11 Jul 2016
Dr Charlotte Warren-Gash has been awarded a 4 year Wellcome Trust Intermediate Clinical Fellowship. This will fund a programme of work on the role of herpes viruses in dementia and stroke, undertaken in collaboration with University College London. Data sources will include the Dominantly Inherited Alzheimer’s Network cohort (DIAN), the Clinical Practice Research Datalink (CPRD), and UK...
Statins controversy linked to rise in UK patients stopping the treatment
30 Jun 2016
New research highlights potential public health impact of high profile health stories in the media. For more information click here. Anthony Matthews, Emily Herrett, Antonio Gasparrini, Antonio, Tjeerd van Staa, Ben Goldacre, Liam Smeeth, Krishnan Bhaskaran, Impact of statin media coverage on the use of statins in the UK: an interrupted time series analysis using primary care data, BMJ. DOI:...
28 Jun 2016
A paper reviewing methodological challenges when carrying out research on chronic and acute kidney disease published. In this paper we systematically explore the issues that may arise in study design and interpretation when using routine data sources for renal research.
Sir Henry Wellcome Postdoctoral Fellowship Awarded
24 Jun 2016
In May 2016, Dr Rohini Mathur was awarded a four year Sir Henry Wellcome Postdoctoral Fellowship, which will commence in April 2017. The aim of the research will be to identify areas of healthcare which can be modified in order to reduce the risk of vascular disease outcomes amongst people with type 2 diabetes. It is known that significant ethnic inequalities exist, both in the prevalence of...
New Paper: Recent Trends in ADHD medication use in UK
24 Jun 2016
Over the last 20 years, children with attention deficit hyperactivity disorder (ADHD) throughout the world have been increasingly treated with medication. This study used primary care prescribing records to look at ADHD medication trends in the UK. We found large increases in the use of ADHD medication between 1992 and 2008, with usage levels then becoming stable since 2008. This paper is...