Renal disease

Our group is conducting a wide portfolio of research studies into aspects of kidney disease. We predominantly use Electronic Health Records and other sources of routine data. We are always interested in new collaborations and if you are interested in working with us please get in touch.

National Chronic Kidney Disease Audit

The National CKD Audit is being implemented in England and Wales to provide a comprehensive picture of management and outcomes for people with CKD stages 3-5 in the region. It aims to improve the quality of patient care and assesses each GP practice against NICE CKD quality guidelines and standards to encourage quality improvement.

Acute Kidney Injury

Funded by the Wellcome Trust, we are investigating the epidemiology of acute kidney injury and the role that comorbidities and drugs play in its development. We are contributing to national organisations and campaigns working to improve the care and outcome of people who develop AKI such as the NHS England ‘Think Kidneys’.

Psychiatric illness and kidney disease

We are studying the prevalence and outcomes of kidney disease among people with psychiatric illness with a particular focus on the side-effects of medications in this population.

Diabetes and kidney disease

Previous work looking at the association between CKD and infections among diabetics has led to a broader programme of work studying the effect of diabetes treatments in slowing the development of kidney disease.

General epidemiology of kidney disease

We are studying the impact of a range of risk factors and medications on the development and outcome of people with kidney disease using a number of routine data sources, including the UK renal registry.

Global epidemiology of kidney disease

In addition to our research using EHRs we have a number of national and international collaborations investigating kidney disease in a global health context.

Links to some key publications:

Methodological challenges when carrying out research on CKD and AKI using routine electronic health records.

CKD and the risk of acute, community-acquired infections among older people with diabetes mellitus: a retrospective cohort study using electronic health records.

Are pre-existing markers of chronic kidney disease associated with short-term mortality following acute community-acquired pneumonia and sepsis? A cohort study among older people with diabetes using electronic health records.

Inpatient coronary angiography and revascularisation following non-ST-elevation acute coronary syndrome in patients with renal impairment: a cohort study using the Myocardial Ischaemia National Audit Project.

Incomplete reversibility of estimated glomerular filtration rate decline following tenofovir disoproxil fumarate exposure.

Association between glycemia and mortality in diabetic individuals on renal replacement therapy in the U.K.

Baseline kidney function as predictor of mortality and kidney disease progression in HIV-positive patients.

Comparison of CKD-EPI and MDRD to estimate baseline renal function in HIV-positive patients.

Disparities in testing for renal function in UK primary care: cross-sectional study.

Patterns and effects of missing comorbidity data for patients starting renal replacement therapy in England, Wales and Northern Ireland.

Outcomes in patients on home haemodialysis in England and Wales, 1997-2005: a comparative cohort analysis.

Erythropoiesis-stimulating agent dosing, haemoglobin and ferritin levels in UK haemodialysis patients 2005-13.