Respiratory

Respiratory diseases are diseases that affect the airways, the bronchi and the lungs. They include acute infections, such as pneumonia and bronchitis, and chronic conditions such as asthma and chronic obstructive pulmonary disease.

Using large electronic databases, we study the long-term effects and outcomes of treatment for these chronic respiratory diseases. Asthma and COPD are very common illnesses, in which patients suffer from episodes of acute deteriorations of respiratory function termed exacerbations. There is increasing understanding that asthma and COPD are part of a spectrum of obstructive airway diseases consisting of complex subtypes which share certain characteristics (phenotypes) but differ in terms of prognosis.

Past work includes validation studies of COPD and acute COPD exacerbations in UK primary care electronic healthcare records and an ongoing validation study of asthma using the same data source. Other work focuses on the cardiovascular risk profile of COPD patients.

Currently, we are studying treatment patterns and control of different asthma phenotypes in the UK primary care electronic records.

Links to publications:

The risk of myocardial infarction (MI) and death following MI in people with chronic obstructive pulmonary disease: A systematic review and meta-analysis.

Predicting mortality after acute coronary syndromes in people with chronic obstructive pulmonary disease.

COPD disease severity and the risk of venous thromboembolic events: a matched case-control study.

Changes in the incidence, prevalence and mortality of bronchiectasis in the UK from 2004 to 2013: a population-based cohort study.