Adrian Root

I am interested in the effect of drug-drug interactions in primary care. My PhD will explore the population level risk from drug-drug interactions by investigating how frequently these drug combinations are prescribed in primary care and for specific examples, what the risk of harm is. My supervisors are Dr Ian Douglas and Prof Liam Smeeth.

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Related Publications

Cardiovascular outcomes associated with use of clarithromycin: population based study.

Wong, AY. Root, A. Douglas, IJ. Chui, CS. Chan, EW. Ghebremichael-Weldeselassie, Y. Siu, CW. Smeeth, L. Wong, IC.
BMJ, 2016; 352:h6926.

Evaluation of the risk of cardiovascular events with clarithromycin using both propensity score and self-controlled study designs.

Root, A.A. ; Wong, A.Y. ; Ghebremichael-Weldeselassie, Y. ; Smeeth, L. ; Bhaskaran, K. ; Evans, S.J. ; Brauer, R. ; Wong, I.C. ; Navaratnam, V. ; Douglas, I. ;
Evaluation of the risk of cardiovascular events with clarithromycin using both propensity score and self-controlled study designs.
Br J Clin Pharmacol, 2016;

Association between oral fluoroquinolones and seizures: A self-controlled case series study.

Chui, C.S. ; Chan, E.W. ; Wong, A.Y. ; Root, A. ; Douglas, I.J. ; Wong, I.C. ;
Association between oral fluoroquinolones and seizures: A self-controlled case series study.
Neurology, 2016;

OS 04-07 THE COMPARATIVE EFFECTIVENESS OF 4TH LINE ANTI-HYPERTENSIVE AGENTS IN PATIENTS WITH RESISTANT HYPERTENSION: A META-ANALYSIS.

Sinnott, S.J. ; Root, A. ; Mathur, R. ; Mansfield, K. ; Tomlinson, L. ; Douglas, I. ;
OS 04-07 THE COMPARATIVE EFFECTIVENESS OF 4TH LINE ANTI-HYPERTENSIVE AGENTS IN PATIENTS WITH RESISTANT HYPERTENSION: A META-ANALYSIS.
J Hypertens, 2016; 34 Suppl 1 – ISH 2016 Abstract Book:e56-e57

Comparative effectiveness of fourth-line anti-hypertensive agents in resistant hypertension: A systematic review and meta-analysis.

Sinnott, S.J. ; Tomlinson, L.A. ; Root, A.A. ; Mathur, R. ; Mansfield, K.E. ; Smeeth, L. ; Douglas, I.J. ;
Comparative effectiveness of fourth-line anti-hypertensive agents in resistant hypertension: A systematic review and meta-analysis.
Eur J Prev Cardiol, 2016;

Oral Fluoroquinolone Use and Retinal Detachment.

Douglas, I.J. ; Root, A. ; Krishnan, B. ;
Oral Fluoroquinolone Use and Retinal Detachment.
JAMA Ophthalmol, 2016;

OS 04-07 THE COMPARATIVE EFFECTIVENESS OF 4TH LINE ANTI-HYPERTENSIVE AGENTS IN PATIENTS WITH RESISTANT HYPERTENSION: A META-ANALYSIS.

Sinnott, S.J. ; Root, A. ; Mathur, R. ; Mansfield, K. ; Tomlinson, L. ; Douglas, I. ;
OS 04-07 THE COMPARATIVE EFFECTIVENESS OF 4TH LINE ANTI-HYPERTENSIVE AGENTS IN PATIENTS WITH RESISTANT HYPERTENSION: A META-ANALYSIS.
J Hypertens, 2016; 34 Suppl 1 – ISH 2016 Abstract Book:e56-e57

Quantification of the risk of liver injury associated with flucloxacillin: a UK population-based cohort study.

Wing, K. ; Bhaskaran, K. ; Pealing, L. ; Root, A. ; Smeeth, L. ; van Staa, T.P. ; Klungel, O.H. ; Reynolds, R.F. ; Douglas, I. ;
Quantification of the risk of liver injury associated with flucloxacillin: a UK population-based cohort study.
J Antimicrob Chemother, 2017; 72(9):2636-2646

Re: Biomedical Informatics Approaches to Identifying Drug-Drug Interactions: Application to Insulin Secretagogues.

Root, A. ; Douglas, I. ; Evans, S. ;
Re: Biomedical Informatics Approaches to Identifying Drug-Drug Interactions: Application to Insulin Secretagogues.
Epidemiology, 2017;

Cardiovascular Outcomes Following a Respiratory Tract Infection among Adults with Non-CF Bronchiectasis: A General Population Based Study.

Navaratnam, V. ; Root, A.A. ; Douglas, I. ; Smeeth, L. ; Hubbard, R.B. ; Quint, J.K. ;
Cardiovascular Outcomes Following a Respiratory Tract Infection among Adults with Non-CF Bronchiectasis: A General Population Based Study.
Ann Am Thorac Soc, 2017;

Inequalities in zoster disease burden: a population-based cohort study to identify social determinants using linked data from the UK Clinical Practice Research Datalink.

Jain, A. ; van Hoek, A.J. ; Walker, J.L. ; Forbes, H.J. ; Langan, S.M. ; Root, A. ; Smeeth, L. ; Thomas, S.L. ;
Inequalities in zoster disease burden: a population-based cohort study to identify social determinants using linked data from the UK Clinical Practice Research Datalink.
Br J Dermatol, 2018;