Laurie Tomlinson

Current research/interests: My research is in the epidemiology of kidney disease, particularly kidney related side-effects of commonly prescribed drugs. My main current project is researching the epidemiology of acute kidney injury and the role that infections and medications play in its development. In addition my group is studying the association between mental health problems and kidney disease, examining the renal effects of different treatments for diabetes, and the benefits of different treatments for hypertension. I am currently funded by a Wellcome Intermediate Fellowship and also work as a Consultant Nephrologist at Brighton and Sussex University Hospitals NHS Trust. Before coming to LSHTM my research focussed on the overlap between cardiovascular disease and chronic kidney disease, and I am involved in a number of ongoing projects in this area.

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Related Publications

Diagnosis of acute kidney injury and its association with in-hospital mortality in patients with infective exacerbations of bronchiectasis: cohort study from a UK nationwide database.

Iwagami, M. Mansfield, K. Quint, J. Nitsch, D. Tomlinson, L. 
BMC Pulm Med, 2016; 16(1):14.

The risks and benefits of patients temporarily discontinuing medications in the event of an intercurrent illness: a systematic review protocol.

Morden, A. ; Horwood, J. ; Whiting, P. ; Savovic, J. ; Tomlinson, L. ; Blakeman, T. ; Tomson, C. ; Richards, A. ; Stone, T. ; Caskey, F. ;
The risks and benefits of patients temporarily discontinuing medications in the event of an intercurrent illness: a systematic review protocol.
Syst Rev, 2015; 4(1):139

Acute kidney injury-how does automated detection perform?

Sawhney, S. Fluck, N. Marks, A. Prescott, G. Simpson, W. Tomlinson, L. Black, C.
Nephrol Dial Transplant, 2015 Nov;30(11):1853-61.

Reduced Renal Methylarginine Metabolism Protects against Progressive Kidney Damage.

Tomlinson, JA. Caplin, B. Boruc, O. Bruce-Cobbold, C. Cutillas, P. Dormann, D. Faull, P. Grossman, RC. Khadayate, S. Mas, V.R. Nitsch, DD. Wang, Z. Norman, JT. Wilcox, CS. Wheeler, DC. Leiper, J.
J Am Soc Nephrol, 2015;26(12):3045-59.

Methodological challenges when carrying out research on CKD and AKI using routine electronic health records.

McDonald, H.I. ; Shaw, C. ; Thomas, S.L. ; Mansfield, K.E. ; Tomlinson, L.A. ; Nitsch, D. ;
Methodological challenges when carrying out research on CKD and AKI using routine electronic health records.
Kidney Int, 2016;

OS 04-07 THE COMPARATIVE EFFECTIVENESS OF 4TH LINE ANTI-HYPERTENSIVE AGENTS IN PATIENTS WITH RESISTANT HYPERTENSION: A META-ANALYSIS.

Sinnott, S.J. ; Root, A. ; Mathur, R. ; Mansfield, K. ; Tomlinson, L. ; Douglas, I. ;
OS 04-07 THE COMPARATIVE EFFECTIVENESS OF 4TH LINE ANTI-HYPERTENSIVE AGENTS IN PATIENTS WITH RESISTANT HYPERTENSION: A META-ANALYSIS.
J Hypertens, 2016; 34 Suppl 1 – ISH 2016 Abstract Book:e56-e57

Comparative effectiveness of fourth-line anti-hypertensive agents in resistant hypertension: A systematic review and meta-analysis.

Sinnott, S.J. ; Tomlinson, L.A. ; Root, A.A. ; Mathur, R. ; Mansfield, K.E. ; Smeeth, L. ; Douglas, I.J. ;
Comparative effectiveness of fourth-line anti-hypertensive agents in resistant hypertension: A systematic review and meta-analysis.
Eur J Prev Cardiol, 2016;

Prescription of renin-angiotensin system blockers and risk of acute kidney injury: a population-based cohort study.

Mansfield, K.E. ; Nitsch, D. ; Smeeth, L. ; Bhaskaran, K. ; Tomlinson, L.A. ;
Prescription of renin-angiotensin system blockers and risk of acute kidney injury: a population-based cohort study.
BMJ Open, 2016; 6(12):e012690

OS 04-07 THE COMPARATIVE EFFECTIVENESS OF 4TH LINE ANTI-HYPERTENSIVE AGENTS IN PATIENTS WITH RESISTANT HYPERTENSION: A META-ANALYSIS.

Sinnott, S.J. ; Root, A. ; Mathur, R. ; Mansfield, K. ; Tomlinson, L. ; Douglas, I. ;
OS 04-07 THE COMPARATIVE EFFECTIVENESS OF 4TH LINE ANTI-HYPERTENSIVE AGENTS IN PATIENTS WITH RESISTANT HYPERTENSION: A META-ANALYSIS.
J Hypertens, 2016; 34 Suppl 1 – ISH 2016 Abstract Book:e56-e57

Pharmacoepidemiology for nephrologists: do proton pump inhibitors cause chronic kidney disease?

Tomlinson, L.A. ; Fogarty, D.G. ; Douglas, I. ; Nitsch, D. ;
Pharmacoepidemiology for nephrologists: do proton pump inhibitors cause chronic kidney disease?
Nephrol Dial Transplant, 2017;

Validity of estimated prevalence of decreased kidney function and renal replacement therapy from primary care electronic health records compared with national survey and registry data in the United Kingdom.

Iwagami, M. ; Tomlinson, L.A. ; Mansfield, K.E. ; Casula, A. ; Caskey, F.J. ; Aitken, G. ; Fraser, S.D. ; Roderick, P.J. ; Nitsch, D. ;
Validity of estimated prevalence of decreased kidney function and renal replacement therapy from primary care electronic health records compared with national survey and registry data in the United Kingdom.
Nephrol Dial Transplant, 2017;

Adherence to guidelines for creatinine and potassium monitoring and discontinuation following renin-angiotensin system blockade: a UK general practice-based cohort study.

Schmidt, M. ; Mansfield, K.E. ; Bhaskaran, K. ; Nitsch, D. ; Sørensen, H.T. ; Smeeth, L. ; Tomlinson, L.A. ;
Adherence to guidelines for creatinine and potassium monitoring and discontinuation following renin-angiotensin system blockade: a UK general practice-based cohort study.
BMJ Open, 2017; 7(1):e012818

Serum creatinine elevation after renin-angiotensin system blockade and long term cardiorenal risks: cohort study.

Schmidt, M. ; Mansfield, K.E. ; Bhaskaran, K. ; Nitsch, D. ; Sørensen, H.T. ; Smeeth, L. ; Tomlinson, L.A. ;
Serum creatinine elevation after renin-angiotensin system blockade and long term cardiorenal risks: cohort study.
BMJ, 2017; 356:j791

Prevalence, incidence, indication, and choice of antidepressants in patients with and without chronic kidney disease: a matched cohort study in UK Clinical Practice Research Datalink.

Iwagami, M. ; Tomlinson, L.A. ; Mansfield, K.E. ; McDonald, H.I. ; Smeeth, L. ; Nitsch, D. ;
Prevalence, incidence, indication, and choice of antidepressants in patients with and without chronic kidney disease: a matched cohort study in UK Clinical Practice Research Datalink.
Pharmacoepidemiol Drug Saf, 2017;

Risk factors for developing acute kidney injury in older people with diabetes and community-acquired pneumonia: a population-based UK cohort study.

Jain A, McDonald HI, Nitsch D, Tomlinson L, Thomas SL.

What are the risks and benefits of temporarily discontinuing medications to prevent acute kidney injury? A systematic review and meta-analysis.

Whiting, P. ; Morden, A. ; Tomlinson, L.A. ; Caskey, F. ; Blakeman, T. ; Tomson, C. ; Stone, T. ; Richards, A. ; Savović, J. ; Horwood, J. ;
What are the risks and benefits of temporarily discontinuing medications to prevent acute kidney injury? A systematic review and meta-analysis.
BMJ Open, 2017; 7(4):e012674

Risk factors for developing acute kidney injury in older people with diabetes and community-acquired pneumonia: a population-based UK cohort study.

Jain, A. ; McDonald, H.I. ; Nitsch, D. ; Tomlinson, L. ; Thomas, S.L. ;
Risk factors for developing acute kidney injury in older people with diabetes and community-acquired pneumonia: a population-based UK cohort study.
BMC Nephrol, 2017; 18(1):142

Seventeen-Year Nationwide Trends in Antihypertensive Drug Use in Denmark.

Sundbøll, J. ; Adelborg, K. ; Mansfield, K.E. ; Tomlinson, L.A. ; Schmidt, M. ;
Seventeen-Year Nationwide Trends in Antihypertensive Drug Use in Denmark.
Am J Cardiol, 2017;

Biochemical monitoring after initiation of aldosterone antagonist therapy in users of renin-angiotensin system blockers: a UK primary care cohort study.

Sinnott, S.J. ; Mansfield, K.E. ; Schmidt, M. ; Bhaskaran, K. ; Smeeth, L. ; Nitsch, D. ; Tomlinson, L.A. ;
Biochemical monitoring after initiation of aldosterone antagonist therapy in users of renin-angiotensin system blockers: a UK primary care cohort study.
BMJ Open, 2017; 7(11):e018153

Lansoprazole use and tuberculosis incidence in the United Kingdom Clinical Practice Research Datalink: A population based cohort.

Yates, T.A. ; Tomlinson, L.A. ; Bhaskaran, K. ; Langan, S. ; Thomas, S. ; Smeeth, L. ; Douglas, I.J. ;
Lansoprazole use and tuberculosis incidence in the United Kingdom Clinical Practice Research Datalink: A population based cohort.
PLoS Med, 2017; 14(11):e1002457

Acute kidney injury and infections in patients taking antihypertensive drugs: a self-controlled case series analysis.

Mansfield, K.E. ; Douglas, I.J. ; Nitsch, D. ; Thomas, S.L. ; Smeeth, L. ; Tomlinson, L.A. ;
Acute kidney injury and infections in patients taking antihypertensive drugs: a self-controlled case series analysis.
Clin Epidemiol, 2018; 10:187-202


Codelists available
Trimethoprim use for urinary tract infection and risk of adverse outcomes in older patients: cohort study.

Crellin, E. ; Mansfield, K.E. ; Leyrat, C. ; Nitsch, D. ; Douglas, I.J. ; Root, A. ; Williamson, E. ; Smeeth, L. ; Tomlinson, L.A. ;
Trimethoprim use for urinary tract infection and risk of adverse outcomes in older patients: cohort study.
BMJ, 2018; 360:k341

How does the association of general and central adiposity with glycaemia and blood pressure differ by gender and area of residence in a Malawian population: a cross-sectional study.

Mudie, K. ; Lawlor, D.A. ; Pearce, N. ; Crampin, A. ; Tomlinson, L. ; Tafatatha, T. ; Musicha, C. ; Nitsch, D. ; Smeeth, L. ; Nyirenda, M.J. ;
How does the association of general and central adiposity with glycaemia and blood pressure differ by gender and area of residence in a Malawian population: a cross-sectional study.
Int J Epidemiol, 2018;

Severe mental illness and chronic kidney disease: a cross-sectional study in the United Kingdom.

Iwagami, M. ; Mansfield, K.E. ; Hayes, J.F. ; Walters, K. ; Osborn, D.P. ; Smeeth, L. ; Nitsch, D. ; Tomlinson, L.A. ;
Severe mental illness and chronic kidney disease: a cross-sectional study in the United Kingdom.
Clin Epidemiol, 2018; 10:421-429

Gastrointestinal bleeding risk of selective serotonin reuptake inhibitors by level of kidney function: a population-based cohort study.

Iwagami, M. ; Tomlinson, L.A. ; Mansfield, K.E. ; Douglas, I.J. ; Smeeth, L. ; Nitsch, D. ;
Gastrointestinal bleeding risk of selective serotonin reuptake inhibitors by level of kidney function: a population-based cohort study.
Br J Clin Pharmacol, 2018;

A systematic review comparing the evidence for kidney function outcomes between oral antidiabetic drugs for type 2 diabetes.

Wilkinson, S.V. ; Tomlinson, L.A. ; Iwagami, M. ; Stirnadel-Farrant, H.A. ; Smeeth, L. ; Douglas, I. ;
A systematic review comparing the evidence for kidney function outcomes between oral antidiabetic drugs for type 2 diabetes.
Wellcome Open Res, 2018; 3:74

Changing use of antidiabetic drugs in the UK: trends in prescribing 2000-2017.

Wilkinson, S. ; Douglas, I. ; Stirnadel-Farrant, H. ; Fogarty, D. ; Pokrajac, A. ; Smeeth, L. ; Tomlinson, L. ;
Changing use of antidiabetic drugs in the UK: trends in prescribing 2000-2017.
BMJ Open, 2018; 8(7):e022768

Chronic kidney disease and cause-specific hospitalisation: a matched cohort study using primary and secondary care patient data.

Iwagami, M. ; Caplin, B. ; Smeeth, L. ; Tomlinson, L.A. ; Nitsch, D. ;
Chronic kidney disease and cause-specific hospitalisation: a matched cohort study using primary and secondary care patient data.
Br J Gen Pract, 2018;